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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: J Neurosci Res. 2019 Jul 12;97(12):1559–1578. doi: 10.1002/jnr.24494

FIGURE 8.

FIGURE 8

The degree of locomotor sensitization correlates with synaptic potentiation in individual mice. (a) Locomotor ambulations in response to treatment with saline or amphetamine. The number of mice (n) is indicated in parenthesis. (b) Locomotor ambulations of individual amphetamine-treated mice from the behavioral experiments shown in Figure 8a. (c) The percent increase in locomotor ambulations for individual mice shown in Figure 8a, when normalized to ambulations on the first day of amphetamine (experiment day 3). (d) The percent increase in corticostriatal release (potentiation) following an amphetamine challenge in vitro on WD 50, measured in slices from amphetamine-treated mice (shown in Figure 8a). (e) Percent increase in ambulations on experiment days 4-7 is compared to the percent increase in corticostriatal release on WD 50. (f) The percent increase in ambulations following an amphetamine challenge in vivo on challenge days 1 and 2 (experiment day 17 and 28) is compared to the percent increase in corticostriatal release (potentiation) on WD 50.