Table 3:
Intratumoral F. nucleatum burden correlates with worse chemotherapeutic response in ESCC patients
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| RECIST | ||||
| Age (vs >= 65) | 1.47 (0.65 – 3.41) | 0.35 | ||
| Male (vs Female) | 2.42 (0.68 – 11.3) | 0.18 | ||
| Upper tumor location (vs lower) | 1.14 (0.48 – 2.74) | 0.77 | ||
| T category, 3–4 (vs 1–2) | 0.83 (0.34 – 2.03) | 0.68 | ||
| Lymph node metastasis | 5.88 (1.02 – 111) | 0.04 | 6.95 (1.19 – 135) | 0.03 |
| F. nucleatum High (vs Low ) | 2.72 (1.12 – 6.78) | 0.03 | 2.97 (1.19 – 7.73) | 0.02 |
| PET/CT | ||||
| Age (vs >= 65) | 1.65 (0.57 – 5.18) | 0.35 | ||
| Male (vs Female) | 2.10 (0.34 – 40.6) | 0.47 | ||
| Upper tumor location (vs lower) | 0.92 (0.32 – 2.93) | 0.89 | ||
| T category, 3–4 (vs 1–2) | 10.0 (1.89 – 186) | 0.004 | 9.74 (1.66 – 187) | 0.008 |
| Lymph node metastasis | 0.43 (0.09 – 2.27) | 0.3 | ||
| F. nucleatum High (vs Low) | 7.84 (2.58 – 25.4) | 0.0003 | 7.66 (2.37 – 26.8) | 0.0006 |
| TRG | ||||
| Age (vs >= 65) | 0.56 (0.20 – 1.49) | 0.25 | ||
| Male (vs Female) | 0.25 (0.01 – 1.38) | 0.13 | ||
| Upper tumor location (vs lower) | 1.53 (0.57 – 4.02) | 0.39 | ||
| T category, 3–4 (vs 1–2) | 2.56 (0.95 – 6.85) | 0.06 | 2.05 (0.74 – 5.70) | 0.17 |
| Lymph node metastasis | 1.88 (0.36 – 7.48) | 0.45 | ||
| F. nucleatum High (vs Low) | 11.6 (2.25 – 214) | 0.001 | 10.3 (1.96 – 190) | 0.003 |