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. Author manuscript; available in PMC: 2020 Apr 15.
Published in final edited form as: Cancer Res. 2019 Aug 20;79(20):5394–5406. doi: 10.1158/0008-5472.CAN-19-0381

Figure 6.

Figure 6.

Immuno-NPs mediate the prevention of metastasis in the 4T1 model. (a) Bioluminescence quantification of lung/lymph node metastasis signal for each treatment group (N=5–7 mice per group). Black arrows along x-axis designate treatment days. (h) Representative bioluminescence images of metastasis. Units of radiance are photons/s. Flow cytometry analysis of immune cells per gram of tumor tissue (c), NP+ cells (d), representative dot plots (e), NP signal per NP+ cell (f), and IFNβ per cell (g) (N=4 mice per group). Mean ± standard error are plotted with statistics by 1-/2-way ANOVA with Tukey’s post-test (* P<0.05, ** P<0.01, *** P<0.001, *** P<0.0001). Confocal microscopy of metastatic lung tissue sections with staining for DCs (h), macrophages (i), and NK cells (j). White arrows indicate areas with immuno-NPs. Scale bars are 100 μm.