Table 2.
Participant characteristics of studies included in the pooled analysis on CRP and ovarian cancer risk from the Ovarian Cancer Cohort Consortium
| CLUEII | EPIC | NHS | NHSII | NYUWHS | PLCO | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) or % | Mean (SD) or % | Mean (SD) or % | Mean (SD) or % | Mean (SD) or % | Mean (SD) or % | |||||||
| Cases (n=52) | Controls (n=97) | Cases (n=581) | Controls (n=1101) | Cases (n=217) | Controls (n=431) | Cases (n=50) | Controls (n=100) | Cases (n=48) | Controls (n=77) | Cases (n=143) | Controls (n=145) | |
| Batch-corrected CRP | 2.8 (2.7) | 2.3 (2.9) | 2.8 (4.5) | 2.6 (5.0) | 2.6 (3.8) | 2.7 (4.8) | 3.8 (9.1) | 2.1 (3.0) | 2.2 (3.3) | 1.8 (2.1) | 3.8 (4.3) | 3.6 (4.4) |
| Age at blood draw, yrs | 59.5 (14.5) | 59.0 (14.5) | 55.8 (8.1) | 55.7 (8.1) | 56.8 (6.6) | 56.7 (6.5) | 44.9 (4.8) | 45.1 (4.7) | 52.2 (8.9) | 51.8 (8.7) | 63.4 (5.5) | 63.1 (5.4) |
| Age at diagnosis, yrs | 66.3 (14.8) | 62.4 (8.6) | 67.5 (8.0) | 51.1 (5.8) | 59.3 (8.9) | 71.2 (6.1) | ||||||
| BMI, kg/m2 | 26.4 (5.8) | 25.5 (4.7) | 26.2 (4.8) | 25.9 (4.5) | 24.6 (4.5) | 25.0 (4.4) | 27.3 (7.7) | 25.8 (5.8) | 24.8 (4.0) | 26.0 (4.4) | 26.6 (5.1) | 26.9 (5.4) |
| Parity | 1.7 (1.0) | 2.0 (1.2) | 1.9 (1.3) | 2.1 (1.3) | 2.9 (1.6) | 3.3 (1.6) | 1.5 (1.5) | 1.8 (1.3) | 1.2 (1.3) | 1.4 (1.2) | 2.8 (1.4) | 2.9 (1.4) |
| Fasting | 26.9 | 18.6 | 27.4 | 27.7 | 62.7 | 66.8 | 66.0 | 70.0 | 18.8 | 10.4 | 0.0 | 0.0 |
| Menopausal status at blood draw | ||||||||||||
| Premenopausal | 19.2 | 20.6 | 31.8 | 32.2 | 36.0 | 36.2 | 88.0 | 88.0 | 50.0 | 52.0 | 0.0 | 0.0 |
| Postmenopausal, using HT | 13.5 | 9.3 | 18.2 | 18.4 | 30.9 | 29.7 | 4.0 | 4.0 | 0.0 | 0.0 | 51.0 | 43.5 |
| Postmenopausal, not using HT | 67.3 | 70.1 | 49.9 | 49.5 | 33.2 | 34.1 | 8.0 | 8.0 | 50.0 | 48.0 | 49.0 | 56.6 |
| Oral contraceptive use | ||||||||||||
| Never | 76.9 | 82.5 | 56.1 | 49.9 | 55.3 | 53.6 | 14.0 | 14.0 | 45.8 | 44.2 | 54.6 | 49.0 |
| Ever | 23.1 | 17.5 | 43.4 | 49.6 | 44.7 | 46.4 | 86.0 | 86.0 | 25.0 | 27.3 | 45.5 | 51.0 |
| Unknown | 0.0 | 0.0 | 0.5 | 0.5 | 0.0 | 0.0 | 0.0 | 0.0 | 29.2 | 28.6 | 0.0 | 0.0 |
| Tubal ligation | NR | NR | 3.1 | 2.7 | 16.1 | 17.9 | 14.0 | 29.0 | 0.0 | 2.6 | 18.2 | 21.4 |
| Smoking | ||||||||||||
| Never | 75.0 | 61.9 | 58.0 | 60.0 | 45.6 | 47.1 | 64.0 | 75.0 | 50.0 | 58.4 | 52.5 | 62.8 |
| Past | 9.6 | 27.8 | 22.6 | 21.3 | 42.4 | 39.7 | 28.0 | 16.0 | 33.3 | 28.6 | 39.2 | 26.9 |
| Current | 15.4 | 10.3 | 19.4 | 18.7 | 12.0 | 13.2 | 8.0 | 9.0 | 16.7 | 13.0 | 8.4 | 10.3 |
| Family history of breast or ovarian cancera | 13.5 | 6.2 | 4.3 | 2.5 | 18.0 | 11.6 | 12.0 | 13.0 | 33.3 | 22.1 | 16.8 | 13.8 |
| Histology | ||||||||||||
| Serous | 44.2 | 54.4 | 61.3 | 48.0 | 64.6 | 52.5 | ||||||
| Endometrioid | 9.6 | 10.5 | 9.2 | 16.0 | 6.3 | 7.7 | ||||||
| Mucinous | 5.8 | 6.4 | 8.3 | 8.0 | 6.3 | 1.4 | ||||||
| Clear cell | 3.9 | 4.5 | 3.2 | 12.0 | 8.3 | 1.4 | ||||||
| Other/missing | 36.5 | 24.3 | 18.0 | 16.0 | 14.6 | 37.1 | ||||||
Abbreviations: NR: not reported; SD: standard deviation; CRP: C-reactive protein; BMI: body mass index; HT: hormone therapy
a
In EPIC and NYU WHS, family history of ovarian cancer was not reported.