Table 4.

Sodium channels

Gene name (s)	Cancer	Role	Functional activity
SCN1A/Nav1.1	Colorectal	Oncogene	Time to reoccurrence of stage II and III CRC is shorter in patients carrying Nav1.1 variants[302]
SCN5A/Nav1.5	Colorectal	Oncogene	Expression up-regulated; mediates invasion via MAPK signaling; key regulator of a transcriptional network that includes Wnt/β-catenin signaling; associated with poor patient prognosis; linked to upregulation of ER-β[5,294-296]
SCN8A/Nav1.6	Colorectal	Tumor suppressor	Expression down-regulated in CRC tumor tissues compared with control[303]
SCN9A/Nav1.7	Gastric	Oncogene	Expression up-regulated; mechanistically related to upregulation of MACC1 and NHE1[297]

CRC: Colorectal cancer.