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. 2019 Oct 14;25(38):5850–5861. doi: 10.3748/wjg.v25.i38.5850

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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6-thioguanine nucleotide level and its ratio to thiopurine dose according to nucleoside diphosphate-linked moiety X-type motif 15 R139C diplotype. A: The level of 6-thioguanine nucleotide (6TGN) was much higher in the nucleoside diphosphate-linked moiety X-type motif 15 CC group than in the CT and TT groups [^bP < 0.01, 312.4 pmol/8 × 10⁸ red blood cells (RBC) vs 312.4 pmol/8 × 10⁸ RBC vs 135.8 pmol/8 × 10⁸ RBC]. B: There was no difference in the ratio of the level of 6TGN to the thiopurine dose among these three groups. 6TGN: 6-thioguanine nucleotide; RBC: Red blood cells.