Table 1.
Laboratory parameters of the siblings at diagnosis
| Sibling 1 | Sibling 2 | Sibling 3 | |
| Age of diagnosis, yr | 15 | 11 | 9 |
| BG at presentation, mg/dL BMI, kg/m2 | 403 23 | 448 28.4 | 337 22.4 |
| Mode of presentation of diagnosis | DKA | DKA | DKA |
| HbA1C, % | 10.7 | 11.0 | 10.7 |
| Urinalysis | |||
| Glucose | 4+ | 4+ | 3+ |
| Ketone | 3+ | 3+ | 2+ |
| Serum C-peptide levels, pmol/L | < 33.0 (364-1655) | Undetectable | Low |
| Anti-GAD antibodies, IU/mL (Normal range: 0.0-10.0) | 1561.0 | 1208.8 | 1054.2 |
| Anti-IA-2 Ab | Increased | Increased | Increased |
| TPO Ab, U/mL | Normal | Normal | Normal |
BG: Blood glucose; BMI: Body mass index; DKA: Diabetic ketoacidosis; HbA1C: Glycated hemoglobin; GAD: Glutamic acid decarboxylase; IA-2 Ab: Insulinoma-associated protein-2 antibody; TPO Ab: Thyroid peroxidase antibody.