Table 3.
Neuropsychological test scores by group at baseline and 12 weeks
| Baseline |
12 weeks |
p value | |||
|---|---|---|---|---|---|
| Placebo | Intervention | Placebo | Intervention | ||
| ADAS-cog | 12.48 (3.07) | 12.96 (3.50) | 11.70 (3.34) | 11.20 (3.62) | 0.27 |
| CERAD-K total score | 66.39 (7.14) | 64.56 (8.78) | 74.13 (7.03) | 71.40 (10.44) | 0.59 |
| Verbal Fluency (VF) | 13.35 (3.21) | 12.80 (3.35) | 14.48 (3.13) | 13.52 (4.09) | 0.63 |
| 15-item Boston Naming Test (BNT) | 11.57 (1.70) | 11.52 (2.45) | 12.52 (1.59) | 12.52 (1.98) | 0.90 |
| Mini Mental Status Examination (MMSE) | 26.04 (1.87) | 25.80 (2.65) | 26.26 (2.60) | 25.32 (3.00) | 0.26 |
| Word List Memory (WLM) | 17.39 (2.62) | 16.88 (2.70) | 20.65 (3.10) | 19.60 (4.45) | 0.57 |
| Constructional Praxis (CP) | 10.13 (1.22) | 9.48 (1.50) | 10.26 (1.36) | 9.76 (1.42) | 0.69 |
| Word List Recall (WLR) | 5.30 (0.93) | 5.28 (1.60) | 6.78 (1.28) | 6.60 (1.76) | 0.72 |
| Word List Recognition (WLRc) | 8.65 (1.50) | 8.60 (1.50) | 9.43 (0.66) | 9.40 (0.87) | 0.96 |
| Constructional Recall (CR) | 6.48 (2.45) | 6.04 (2.56) | 8.39 (1.92) | 7.88 (2.30) | 0.92 |
| Trail making A (seconds) | 54.91 (17.33) | 63.44 (24.24) | 46.52 (17.55) | 61.88 (31.05) | 0.24 |
| Trail making B (seconds) | 186.17 (83.04) | 215.13 (86.89) | 159.52 (84.79) | 194.58 (91.27) | 0.77 |
| SMCQ | 5.57 (3.75) | 6.00 (2.77) | 4.83 (3.55) | 4.24 (2.40) | 0.04 |
Data are presented as the mean (SD). CERAD-K total score=VF+BNT+WLM+CP+WLR+WLRc. ADAS-cog: Alzheimer’s Disease Assessment Scale-cognitive subscale, CERAD-K: Korean version of the Consortium to Establish a Registry for Alzheimer’s disease