Table 2.

Schedule of assessment for MAKE BETTER study

			Base-line	1 weeks	2 weeks	3 weeks	6 weeks	9 weeks	3 Month	6 Month	9 Month	12 Month	15 Month	18 Month	21 Month	24 Month
Clinical assessment
	Socio-demographic characteristics		√
	Psychological characteristics
		Personality	√						√			√
		Social support	√						√			√				√
		Stress-related status	√						√			√				√
		Outcomes of depression
		Depressive symptom	√	√	√	√	√	√	√	√	√	√	√	√	√	√
		Functional disability	√	√	√	√	√	√	√	√	√	√	√	√	√	√
		Suicidality	√	√	√	√	√	√	√	√	√	√	√	√	√	√
		Quality of life	√	√	√	√	√	√	√	√	√	√	√	√	√	√
Biological assessment
	Blood biomarker		√									√
	Salivary cortisol (cortisol study only)		√		√		√		√	√
	Electrocardiography		√									√
	Resting BP, body mass index		√		√		√		√	√	√	√	√	√	√	√
Treatment related assessment
	Antidepressants, dosage, duration		√	√	√	√	√	√	√	√	√	√	√	√	√	√
	Adverse events		√	√	√	√	√	√	√	√	√	√	√	√	√	√
	Withdrawal		√	√	√	√	√	√	√	√	√	√	√	√	√	√

MAKE BETTER: MAKE Biomarker discovery for Enhancing anTidepressants Treatment Effect and Response, BP: blood pressure