Table 2.
Laboratory data of HCC and cirrhotic patients as compared to control group
| Parameter | Control (n=15) | Cirrhosis (n=20) | HCC (n=55) |
|---|---|---|---|
| AST activity (U/L) |
24 (15 - 30) | 67.5 (17 – 259) | 89.7 (27.6 – 364.69) $ |
| ALT activity (U/L) |
24 (12 - 33) | 33.5 (17 - 168) | 62.53 (13.35 - 206.5) $ |
| Total bilirubin concentration(mg/dl) |
0.8 (0.5 – 1) | 2.30 (0.7 - 30) | 1.87 (0.71 – 17) $ |
| Albumin concentration (g/dl) | 4.60±0.46 | 2.45±0.67 | 3.42±0.73 $* |
| Hb concentration (g/dl) | 14.17±1.64 | 10.715±1.91 | 12.37±2.07$* |
| WBCs count (x 103/μl |
6.00 (5.40 – 10.20) | 7.20 (2.50 - 37.59) | 6.63 (2.01 – 18.49) |
| Platelet count (x 103/μl) |
311 (199.9 – 402.3) | 101 (26 – 231) | 106.10 (11 – 402) $ |
| AFP (ng/ml) Median (range) |
7.63 (6.03 – 9.24) | 45.39 (8.23 – 206.30) $ | 206.38 (5.93 – 478.08) $ |
| DKK1 (ng/ml) Mean ± SD |
5.88 ± 2.53 | 8.57 ± 3.06 $ | 11.22 ± 2.55 $* |
| AREG (pg/ml) Median (range) |
9.33 (3.43 – 24.19) | 9.17 (3.43 – 19.59) | 14.27(5.46 – 43.44) $* |
Parametric data are represented as mean ± SD while non-parametric data are represented as median (range). AST: Aspartate aminotransferase, ALT: Alanine aminotransferase, Hb: Hemoglobin, WBCs: White blood cells, AFP: Alpha fetoprotein, DKK1: Dickkopf-1, AREG: Amphiregulin, SD: Standard deviation, n = Number of subjects in each group,
$ = Significant against control group at p<0.05,
*
= Significant against cirrhotic group at p<0.05.