Table 2.
Immature PASMC demonstrated increased susceptibility to flavored solutions by calculated LD50s. Cell death documented by lactate dehydrogenase (LDH) assay at variable dosing was used to calculate concentration at which 50% cell death would occur (lethal dose or LD50). Lower LD50s were noted for fetal and neonatal cells consistent with increased susceptibility.
| Fetal | Neonatal | Adult | |
|---|---|---|---|
| Menthol | 0.62 | 0.59 | 1.62 |
| Strawberry | 1.14 | 1.34 | 2.15 |
| Tobacco | 2.23 | 2.95 | 5.60 |
| Vanilla | >10 | 6.61 | >10 |
| PG | >10 | >10 | >10 |
| VG | >10 | 7.19 | >10 |