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Schematic representation of the roles of exo-miRNAs on distant cells and in the cancer microenvironment. Exo-miRNAs released by tumor cells move to the extracellular space to reach near-by cells, such as macrophages, normal epithelial cells, and normal fibroblast. The exosomal cargo is responsible for cellular transformation and enhanced cancer progression. Exosomes can also reach distant cells, by moving along the blood stream.
