Figure 3.

Glut1 expression and trafficking in T cells. The T cell surface expression of Glut 1 is regulated by extrinsic signals. The transcription of the Slc2a1 gene is induced by engagement of TCR and CD28 co-stimulation or by cytokine signaling through phosphorylated STAT5. The translocation of the intracellular pool of Glut1 to the cell surface is mainly regulated by Akt. Akt activation is the result of TCR and CD28 engagement or can be activated by phosphorylated STAT5 through the IL-2 or IL-7 signaling pathways.