Table 1.

Autoimmune diabetes developed by NOD mouse compared to human T1D.

	NOD	Human
Age at onset	> 10 weeks	>6 months–late adolescence
Genetic susceptibility	MHC most important	HLA most important
Autoantigens	Insulin, GAD, IA-2, IA-2b, ZnT8, IGRP, Crhomogranin A	Insulin, GAD, IA-2, IA-2b, ZnT8, IGRP, IAPP, HSP60, Carboxypetidase H
Insulitis	DCs, Macrophages, B cells, NK cells, CD4 & CD8 T cells	DCs, Macrophages, B cells, NK cells, CD4 & CD8 T cells
Ketoacidosis	Mild	Severe
Gender effect	Females predominantly affected	Males and females almost equally affected