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Proteasome inhibitors suppressed cell proliferation of HER2-positive breast cancer cell lines. BT474 and SkBr3 were treated by bortezomib (A), MB132 (B), PSI (C), and lactacystin (D) with various concentrations for three days. Cell viability was performed by MTT assay. The IC50 was calculated by the concentration of inhibitors which can suppress 50% cell viability (E). Results are shown as mean ± SD of three independent experiments.
