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HSP90 inhibitors downregulate ErbB family expressions via the lysosomal pathway. BT474 (A), BT/LR3 (B), SkBr3 (C), and Sk/LR6 (D) cells were co-treated with 1 μM 17AAG and lysosomal inhibitors 1 μM Baf-A1, 10 mM NH4Cl, and 25 μM CQ. Whole cell lysates were subjected to western blot analysis with indicated antibodies. The intensity of bands in western blot was quantitated using Image J, and β-actin was used as the loading control for normalization.
