Table 1.
The lncRNA And microRNA Involved In E-Cadherin Expression In HCC
| Molecules | Expression In HCC | Regulation Of CDH1 | Relevance To HCC | Refs. |
|---|---|---|---|---|
| LncRNA | ||||
| NEF | Down | Positive | FOXA2—LncRNA-NEF—β-catenin—E-cadherin | 135 |
| MITA1 | Up | Negative | AMPK or DNA methylation—MITA1—Slug—E-cadherin | 144 |
| ATB | Up | Negative | TGF-βactivity—LncRNA-ATB—combinemiR-200—ZEB1ZEB2—E-cadherin | 131 |
| H19 | Up | Negative | TGF-β—Sox2—H19—miR-15b—CDC42/PAK1—E-cadherin | 133,166 |
| HULC | Up | Negative | HULC decoy—miR-200a-3p—ZEB1—E-cadherin | 139 |
| HOTAIR | Up | Negative | HOTAIR—miR-23b-3p—ZEB1—E-cadherin | 117,140 |
| COX2 | Up | Negative | COX2—E-cadherin | 167 |
| p21 | Down | Positive | LncRNA-p21—decoysmiRNA-9—E-cadherin | 168 |
| UBE2CP3 | Up | Negative | LncRNAUBE2CP3—miR-138-5pN-cadherin, Snail—E-cadherin | 145 |
| Sox2ot | Up | Negative | LncRNASox2ot—Twist1, N-cadherin—E-cadherin | 147 |
| SNHG20 | Up | Negative | LncRNASNHG20—combineEZH2—E-cadherin | 169 |
| SNHG5 | Up | Negative | LncRNASNHG5decoymiR-26a-5p—GSK3β—Wnt/β—E-cadherin | 170 |
| OGFRP1 | Up | Negative | LncRNAOGFRP1—AKT/mTOR, Wnt/B-catenin—E-cadherin | 137 |
| SPRY4-IT1 | Up | Negative | LncRNASPRY4-IT1—Twist1, Vimentin—E-cadherin Or, SPRY4-IT1—combineEZH2—E-cadherin | 148 |
| PVY1 | Up | Negative | LncRNAPVT1—guideEZH2—miR-214Or, PVT1—E-cadherin | 171 |
| CARLo-5 | Up | Negative | LncRNA—Twist1, ZEB1—E-cadherin | 141 |
| UCA1 | Up | Negative | LncRNA—miR-203—Snail2—E-cadherin | 146 |
| Linc00152 | Up | Negative | Linc00152—combineEZH2—E-cadherin | 172 |
| BANCER | Up | Negative | LncRNA BANCER—E-cadherin | 173 |
| CCAT2 | Up | Negative | LncRNACCAT2—snail—E-cadherin | 174 |
| DQ786243(LncDQ) | Up | Negative | LncDQ—EZH2—combineH3K27me3—E-cadherin | 175 |
| ZEB1-AS1 | Up | Negative | LncRNAZEB1-AS1—E-cadherin | 142 |
| HOST2 | Up | Negative | LncRNAHOST2—JAK2-STAT3/or Snail, Slug, Twist-E-cadherin | 176 |
| Linc00857 | Up | Negative | LINC00857—E-cadherin | 177 |
| CRNDE | Up | Negative | CRANDE—Wnt/β-catenin—E-cadherin | 138 |
| NRON | Down | Positive | LncRNA NRON—snail, catenin, E-cadherin | 178 |
| AK021443 | Up | Negative | AK021443—E-cadherin,Snail | 179 |
| Microrna | ||||
| Mir-199-3p | Down | Positive | 199-3p—Notch1—E-cadherin | 180 |
| Mir-186 | Up | Negative | RUNX3combinemir-186promotorRunx3—mir-186—E-cadherin | 181 |
| Mir-122 | Down | Positive | Mir-122—snail/Wnt/b—E-cadherin | 152-154 |
| Mir-9 | Up | Negative | Mir-9—(direct)E-cadherin | 182,183 |
| Mir-29a | Down | Positive | mir-29a—DNMT—CpG methylation—E-cadherin | 184 |
| Mir-26a-5p | Down | Positive | Mir-26a-5p—E-cadherin | 185 |
| Mir-33a | Down | Positive | Hypoxia, HIFs—mir-33a—twist1—E-cadherin | 186 |
| Mir-133b | Down | Positive | Mir-133b—sirt1—GPC3—Wnt/b-catenin—E-cadherin | 187 |
| Mir-451 | Down | Positive | Mir-451—c-Myc—Erk1/2; or, c-Myc—(GSK-3b?)—snail—E-cadherin | 188 |
| Mir-153 | Down | Positive | Mir-153—snail 3ʹUTR—E-cadherin | 189 |
| Mir-130a-3p | Down | Positive | Mir-130a-3p—Smad4—E-cadherin | 190 |
| Mir-130b | Up | Negative | Mir-130b—PPAR—E-cadherin | 191 |
| Mir-192 | Down | Positive | Mir-192—SLC39A6—snail—E-cadherin | 192 |
| Mir-876-5p | Down | Positive | Mir-876-5p—BCORL1—E-cadherin | 193 |
| Mir-200a/b | Down | Positive | Mir-200—ZEB1/2—E-cadherin | 156,157,194,195 |
| Mir-30c/203a | Down | Positive | HCV core protein—mir-30c/203a—E-cadherin | 196 |
| Mir-16 | Down | Positive | Mir-16—PI3K/Akt—E-cadherin | 197 |
| Mir-26a | Down | Positive | Mir-26a—EZH2mRNA—EZH2—E-cadherin | 198 |
| Mir-655-3p | Down | Positive | 655-3p—ADAM10—E-cadherin | 158 |
| Mir-185 | Down | Positive | Mir-185—six2—E-cadherin | 199 |
| Mir-31 | Down | Positive | Mir-31—HDAC2—E-cadherin | 200 |
| Mir-155 | Down | Positive | TGF-β—mir-155—E-cadherin | 201 |
| Mir-26b | Down | Positive | Mir-26b–USP9X–Smad4orTGF-β–E-cadherin | 202 |
| Mir-148b | Down | Positive | Mir-148b—Wnt/b—E-cadherin | 203 |
| Mir-148a | Down | Positive | Mir-148a—Met/Snail—E-cadherin | 204 |
| Mir-30a-3p | Down | Positive | Mir-30a-3p—E-cadherin | 205 |
| Mir-103 | Up | Negative | Mir-103—LATS2(Hippo)—E-cadherin | 206 |
| Mir-101 | Down | Positive | Mir-101—ZEB1—E-cadherin | 207 |
| Mir-491 | Down | Positive | Mir-491—E-cadherin | 208 |
| Mir-141-3p | Down | Positive | Mir-141-3p—GP73target—E-cadherin | 209 |
| Mir-214-5p | Down | Positive | Mir-214-5p—WASL target—E-cadherin | 159 |
| Mir-152 | Down | Positive | Mir-152—DNMT1—methylation—E-cadherin | 160 |
| Mir-564 | Down | Positive | Mir-564—targetGRB2-ERK1/2-AKT—E-cadherin | 210 |