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. 2019 Oct 16;12:8537–8552. doi: 10.2147/OTT.S217916

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© 2019 Gong et al.

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NCAPG plays a biological role in HCC by activating the PI3K/AKT/FOXO4 pathway.

Notes: (A) Representative images of cell migration abilities in SMMC-7721 and MHCC-97H cells with NCAPG overexpression detected by Transwell migration assays. The values indicate the mean ± SD of three independent experiments (**P<0.01, independent Student’s t-test). (B) Representative images of cell proliferation abilities in HCC-LM3 and Huh-7 cells with NCAPG knockdown siRNA detected by Transwell migration assays. The values indicate the mean ± SD of three independent experiments (**P<0.01, independent Student’s t-test). (C) KEGG pathway analysis of differentially expressed genes when NCAPG was silenced in HCC-LM3 cells. GeneRatio: ratio of the number of differential genes enriched in a certain pathway to the total number of differential genes. (D) Western blot of SMMC-7721 and MHCC-97H cells transfected with NCAPG-overexpression plasmid and treated for 24 hrs with 25 μM LY294002. (E) Western blot of HCC-LM3 and Huh-7 cells transfected with NCAPG siRNA and treated for 24 hrs with 10 μM 740Y-P.

Abbreviations: NCAPG, non-SMC condensin I complex subunit G; HCC, hepatocellular carcinoma.