MMR	Mismatch Repair
LS	Lynch Syndrome
EXAC	Exome Aggregation Consortium
BC	Breast Cancer
AUC	Area Under the Curve
RMSD	Root mean square deviation
RMSF	Root mean square fluctuations
rSASA	Relative solvent accessible surface area
MD	Molecular Dynamics
PD	Protein Distance
KNN	K-nearest neighbors
SVM	Support Vector Machine
WT	Wild-Type
GI	Gastro-Intestinal Cancer
VUS	Variants of Unknown Significance
PMs	Pathogenic Mutations
NPMs	Non-Pathogenic Mutations
ESP	NHLBI-GO Exome Sequencing Project Exome Variant Server
ECS	Evolutionary Conservation Score