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. 2019 Sep 26;20(19):4771. doi: 10.3390/ijms20194771

Table 1.

Antitumour properties of some of the Cannabis derivatives.

Cannabinoid Therapeutic Properties Cell Death Mechanism Reference
Cannabidiol (CBD) Reduced cancer cell viability, inhibits cell proliferation and invasion. Apoptosis and autophagy. [16,17,18]
Tetrahydrocannabinol (THC) Decreased cancer cell proliferation. Induction of p8-ATF-4TRIB3 pro-apoptotic pathway [16,17,18,19]
CBD and THC combined Synergistic inhibition of cellular proliferation. Cell cycle modulation, ROS synthesis, apoptosis and caspase activities. [20]
Cannabigerol (CBG) Decreased cell viability Induced apoptosis (Intrinsic apoptotic pathways) [16]