Table 1.
Cannabinoid | Therapeutic Properties | Cell Death Mechanism | Reference |
---|---|---|---|
Cannabidiol (CBD) | Reduced cancer cell viability, inhibits cell proliferation and invasion. | Apoptosis and autophagy. | [16,17,18] |
Tetrahydrocannabinol (THC) | Decreased cancer cell proliferation. | Induction of p8-ATF-4TRIB3 pro-apoptotic pathway | [16,17,18,19] |
CBD and THC combined | Synergistic inhibition of cellular proliferation. | Cell cycle modulation, ROS synthesis, apoptosis and caspase activities. | [20] |
Cannabigerol (CBG) | Decreased cell viability | Induced apoptosis (Intrinsic apoptotic pathways) | [16] |