Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 28;20(19):4823. doi: 10.3390/ijms20194823

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Scheme of mtCU structure. Mitochondrial calcium uniporter pore-forming subunit (MCU) and regulatory subunits are shown: MICU1 and 2—mitochondrial calcium uptake 1 and 2; MCUb—mitochondrial calcium uniporter dominant negative beta subunit; EMRE—essential MCU regulator. IMS—intermembrane space; NTD—N-terminal domain; CTD—C-terminal domain; TM1, TM2—two helices of the transmembrane domain; CCD—coiled coil domain; DIME—amino acids sequence mediating a Ca²⁺-modulated electrostatic interaction between MCU and MICU1. EF hand—helix-loop-helix structural motif of calcium-binding proteins MICU1 and MICU2. Modified from 10.1038/s41598-019-41996-3 under CC-BY.