Figure 5.

Effects of Ps-K18 on LPS-induced endotoxemia mouse model. (A) Inhibition of cytokine production (mTNF-α and mIL-6) in the serum. (B) Inhibition of cytokine production (mTNF-α and mIL-6) in lung lysates. (C) Reduction of LPS endotoxin by Ps-K18 in serum of the LPS-induced sepsis model. (D) AST, ALT, and BUN levels in the mouse septic shock model induced by LPS. BALB/c mice were pre-treated with 1 mg/kg of peptide, followed by intraperitoneal injection with 15 mg/kg of LPS. Data are presented as means ± standard errors of the mean (*p < 0.05; **p < 0.01; ***p < 0.001; ns. represents no significance) compared to LPS-injected group. All measurements were obtained five times.