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Schematic representation of principal interactions targeted by immune checkpoints inhibitors, including PD-1 (programmed cell death protein) and PD-L1 (programmed cell death ligand 1 protein), CTLA4 (cytotoxic T-lymphocyte antigen 4), B7-1, TCR and MHC (major histocompatibility complex) (with the co-function of CD3 and CD8 molecules) pathways, between T-lymphocytes (T cells) and antigen presenting cells (APCs).
