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. 2019 Sep 27;20(19):4814. doi: 10.3390/ijms20194814

Figure 2.

Figure 2

Model for Pol ε function in plant DNA damage repair (DDR). Pol ε may be directly involved in replicative stress sensing upstream of ATR to trigger checkpoint activation via the two SOG1-dependent and independent pathways, allowing the expression of genes involved in cell-cycle arrest, DNA repair, and nucleotide biosynthesis. In parallel, WEE1 contributes to arrest the cell cycle. The activation of all these mechanisms ultimately leads to fork stabilization and completion of DNA replication and cell survival [49,50].