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. 2019 Sep 30;20(19):4867. doi: 10.3390/ijms20194867

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of tumors generated by transplantation of kidney embryoid bodies. (A) Experimental protocol used. (B,C) Macroscopic aspect of kidney NSG mouse 1 month after transplantation of control (*) or met-IPSC-derived kidney embryoid bodies (**), mouse kidney (arrow). (D,H) Pathological analysis of tumors generated by transplantation of control kidney embryoid bodies at 1 month showing the presence of normal embryoid bodies-like structures expressing kidney differentiation markers. (E–G,I) Pathology of c-met-mutated tumors after transplantation of met-IPSC-derived kidney embryoid bodies at 4 weeks, showing disorganized structures with expression of kidney cancer markers TFE3 and cytokeratin 7. Immature cartilage (arrow). Scale bar: 100 μm.