Figure 1.

Responses of pain behaviors and sensitivity to intra-prostatic capsaicin and LESW therapy. (A): Vehicle injected animal (upper panel) and prostatic pain induced by capsaicin injection, characterized by closing of the eyes and hypo-locomotion (lower figure); (B): eye open score time course after second LESW treatment; (C): locomotion score time course after second LESW treatment. (D): Mechanical allodynia confirmed by Von Frey filament examination. Von Frey filaments with different bending forces were delivered to scrotum. (E,F): Mean withdrawal threshold force to Von Frey stimulation assessed 2 h (E) and 24 h (F) after second LESW therapy. Capsaicin-induced reduction of pain threshold and hypersensitivity, which effects were decreased by LESW treatment in a dose-dependent fashion. * p < 0.05; # p < 0.01; † p < 0.001.