Table 1.
Mechanical allodynia evaluated by von Frey filament examination (n = 8 for each group) *, p < 0.05; **, p < 0.01; ***, p < 0.001; **** p < 0.0001.
| Mean Withdrawal Threshold (g/s) Mean ± SEM |
Significant (Tukey’s Multiple Comparisons Test) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Time (hour) |
Sham | Capsaicin | Cap + LESW 100 | Cap + LESW 200 | Cap + LESW 300 | Cap vs. Sham | Cap + LESW 100 vs. Cap | Cap + LESW 200 vs. Cap | Cap + LESW 300 vs. Cap | |
| 2 h after 2nd LESW | 0.5 | 58.34 ± 3.60 | 26.32 ± 2.41 | 45.56 ± 5.13 | 49.03 ± 4.16 | 48.07 ± 3.18 | **** | * | ** | ** |
| 1 | 59.78 ± 4.43 | 30.70 ± 3.67 | 46.39 ± 1.88 | 60.42 ± 6.11 | 47.50 ± 2.03 | **** | ns | **** | * | |
| 1.5 | 58.69 ± 4.95 | 30.70 ± 4.03 | 45.97 ± 5.34 | 60.00 ± 6.68 | 52.60 ± 2.39 | *** | ns | **** | ** | |
| 2 | 63.33 ± 4.90 | 30.70 ± 2.43 | 44.86 ± 7.58 | 62.64 ± 3.49 | 55.42 ± 3.65 | **** | ns | **** | *** | |
| 24 h after 2nd LESW | 0.5 | 62.22 ± 6.34 | 30.00 ± 1.64 | 42.99 ± 4.64 | 42.57 ± 4.11 | 44.64 ± 2.15 | **** | ns | ns | ns |
| 1 | 78.61 ± 5.88 | 31.11 ± 3.53 | 50.14 ± 5.09 | 55.69 ± 1.73 | 50.94 ± 2.09 | **** | * | *** | ** | |
| 1.5 | 76.04 ± 5.54 | 29.72 ± 4.03 | 49.45 ± 3.83 | 62.64 ± 3.49 | 52.29 ± 1.47 | **** | ** | **** | *** | |
| 2 | 68.22 ± 5.77 | 31.25 ± 4.64 | 44.31 ± 3.56 | 62.00 ± 3.30 | 53.75 ± 4.40 | **** | ns | **** | *** | |