Figure 2.

Regulation of adipose tissue browning: Beige adipocytes are generated by the browning of white adipose tissues in response to numerous stimuli, including cold exposure and activation of β-adrenergic receptors. Subsequently, the transcriptional machinery of the browning program activates the expression of characteristic thermogenic genes, leading to the formation of beige adipocytes. Similar to brown adipocytes, beige adipocytes are rich in mitochondria that express UCP1 and can achieve thermogenesis. Notably, beige adipocytes primarily contribute to energy expenditure rather than to energy storage.