Figure 3.

Chemerin has immune-mediated tumor-suppressive effects in melanoma. In low chemerin-producing melanoma tumors, there is an increased presence of myeloid-derived suppressor cells (MDSCs), plasmacytoid dendritic cells (pDCs), and regulatory T-cells (Tregs), which result in a tumor-promoting immunosuppressive environment. When melanomas produce higher amounts of chemerin, there is a switch to a tumor-suppressing immunogenic environment characterized by increased natural killer (NK) cell and cytotoxic T-cell infiltration and reduced infiltration of MDSCs and pDCs.