Table 5.
Bivariate analysis taking the resistance to treatment, evaluated by the BPRS or PANSS scales, as the dependent variable.
| Resistance to Treatment (BPRS or PANSS) | ||||
|---|---|---|---|---|
| No | Yes | p-Value | ||
| Frequency (%) | Frequency (%) | |||
| Gender | Male | 2 (4.0%) | 23 (47.9%) | <0.001 |
| Female | 48 (96.0%) | 25 (52.1%) | ||
| Consumption of psychoactive substances | No | 50 (100.0%) | 40 (90.9%) | 0.029 |
| Yes | 0 (0.0%) | 4 (9.1%) | ||
| Family history of schizophrenic episodes | No | 38 (76.0%) | 22 (53.7%) | 0.025 |
| Yes | 12 (24.0%) | 19 (46.3%) | ||
| COMT | VV | 16 (32.0%) | 16 (33.3%) | 0.896 |
| VM | 22 (44.0%) | 19 (39.6%) | ||
| MM | 12 (24.0%) | 13 (27.1%) | ||
| DRD2 | CC | 7 (14.9%) | 8 (18.6%) | 0.549 |
| CT | 23 (48.9%) | 24 (55.8%) | ||
| TT | 17 (36.2%) | 11 (25.6%) | ||
| MTHFR | CC | 22 (44.0%) | 18 (37.5%) | 0.609 |
| CT | 19 (38.0%) | 23 (47.9%) | ||
| TT | 9 (18.0%) | 7 (14.6%) | ||
| OPRM1 | AA | 39 (78.0%) | 37 (77.1%) | 0.913 |
| AG | 11 (22.0%) | 11 (22.9%) | ||
| GG | 0 (0.0%) | 0 (0.0%) | ||
| Mean ± SD | Mean ± SD | |||
| Adherence to treatment score (over 8) | 6.40 ± 1.02 | 5.37 ± 1.58 | <0.001 | |
| Time since the beginning of treatment (years) | 2.85 ± 1.91 | 1.82 ± 1.72 | 0.022 | |
| Chlorpromazine equivalent dose (mg) | 851.17 ± 821.37 | 1479.69 ± 1221.38 | 0.004 | |
BPRS: brief psychiatric rating scale; PANSS: positive and negative syndrome scale; SD: Standard deviation; numbers in bold indicate significant associations between variables.