Figure 2.

In vivo L-COSY of a patient with RRMS (PCC) acquired at 3T, using a 64 channel head and neck coil; voxel size 30 × 30 × 30 mm³, increment size 0.8 ms, increments 96, 8 averages per increment, TR 1.5 sec, total experimental time 19 min, acquired vector: 1024 points, acquisition time: 512 ms, spectral width in F2: 2000 Hz, spectral width F1: 1250 Hz.

Cr, Creatine; Chol, Choline; GABA, gamma-aminobutyric acid; Glx, glutamine and glutamate cross peaks; L-COSY, localized correlation spectroscopy; PCC, posterior cingulate cortex; NAA, N-acetylaspartate; NAA-I, III and IV, additional N-acetylaspartate signatures; NAA asp, NAA aspartate moiety; NAAG, N-acetylaspartylglutamate; RRMS, relapsing-remitting multiple sclerosis; Thr, Threonine.