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. 2019 Oct 5;20(19):4929. doi: 10.3390/ijms20194929

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme of capsular polysaccharide (CPS) A biosynthesis in Bacteroides fragilis. The pyruvylation step occurs in the cytoplasm at the stage of the lipid-PP-linked RU precursor. Pyruvylation (WcfO) is indicated by a star. Notably, in contrast to succinoglycan biosynthesis (Figure 2), pyruvylation of the internal Galp of the RU needs to proceed prior to completion of the lipid-PP-linked tetrasaccharide repeat. RU: repeating unit. Monosaccharide symbols are shown according to the Symbol Nomenclature for Glycans (SNFG) [45].