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. 2019 Sep 23;20(19):4717. doi: 10.3390/ijms20194717

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of the extract A. chica on the degree of incapacitation of rats with induced osteoarthritis. The induction of osteoarthritis was done by the injection of MIA (2 mg) in the knee of Wistar rats. After 3 days, the animals received oral saline (CTL−), Meloxicam (CTL + Melox) and extract of A. chica at doses 50, 150, and 450 mg/kg (EHA50, EHA150, and EHA450). After 7, 14, 21, and 28 days of induction, the weight distribution on the hind legs of the animals was measured for the assessment of the incapacity by means of the Weight Bearing test. The data are represented in mean ± standard deviation of the means. The healthy group is represented by animals without osteoarthritis and no treatment (CLEAN). **** represents significant differences, **** with p < 0.0001 comparing the treatments to the saline group.