Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 23;20(19):4717. doi: 10.3390/ijms20194717

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effects of A. chica extract on mechanical hyperalgesia in rats with induced osteoarthritis (OA). The induction of OA was done by the injection of MIA (2 mg) in the knee of Wistar rats. After 3 days, the animals received oral saline (CTL−), Meloxicam (CTL + Melox) and extract of A. chica at doses 50, 150, and 450 mg/kg (EHA50, EHA150, and EHA450). After 7, 14, 21, and 28 days of OA induction, the nociceptive threshold of withdrawal of the affected paw was measured by indirect evaluation with Randall Sellito apparatus. The data are represented in mean ± standard deviation of the means. The healthy group is represented by animals without osteoarthritis and without treatment (CLEAN). ** represents significant differences, with p < 0.005; **** with p < 0.0001 comparing the treatments to the saline group. # represents significant differences, with p < 0.05 comparing the EHA450 with CTL + Melox.