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. 2019 Sep 23;20(19):4717. doi: 10.3390/ijms20194717

Figure 5.

Figure 5

Effects of A. chica extract on mechanical allodynia in rats with induced osteoarthritis (OA). The induction of OA was made by the injection of MIA (2 mg) in the right knee of Wistar rats. After 3 days, the animals received oral saline (CTL−), Meloxicam (CTL + Melox) and A. chica extract at doses 50, 150, and 450 mg/kg (EHA50, EHA150, and EHA450). After 7, 14, 21, and 28 days of OA induction, mechanical allodynia was measured by indirect evaluation with the von Frey test. The data are represented in mean ± standard deviation of the means. The healthy group is represented by animals without osteoarthritis and without treatment (CLEAN). * represents significant differences, with p < 0.05; ** with p < 0.005 comparing the treatments to the saline group.