Skip to main content
. 2019 Sep 28;20(19):4826. doi: 10.3390/ijms20194826

Figure 2.

Figure 2

Selective inhibitor of nuclear export (SINE) compounds reduce cell viability and downregulate XPO1 at the protein level. (A) SINE used within this study. (B) Cell viability assays with SNU-1 (top panel) and SNU-16 (bottom panel) after 72 h treatment with SINE, positive control (Leptomycin B, LMB) or negative control (KPT-301) where n = 3 for both cell lines. All treatment cell counts were normalized to control cell counts. (C) Western blot of time course with SNU-16 cell line after treatment with KPT-330, KPT-8602 or KPT-301 at lower and higher doses (n = 3). Western blot was probed for XPO1 and beta-actin and densitometry analysis was performed using ImageJ and is representative of three independent experiments.