Table 2.
KEGG pathway analysis of the target genes of the differentially expressed miRNAs.
| Down-Regulated miRNAs Target Genes Pathway | ||
|---|---|---|
| Terms | FE 1 | FDR 2 |
| cfa05206:MicroRNAs in cancer | 2.522 | 6.72 × 10−7 |
| cfa04010:MAPK signaling pathway | 1.917 | 1.20 × 10−4 |
| cfa04151:PI3K-Akt signaling pathway | 1.762 | 1.65 × 10−4 |
| cfa04360:Axon guidance | 2.307 | 4.96 × 10−4 |
| cfa05205:Proteoglycans in cancer | 1.981 | 8.64 × 10−4 |
| cfa04910:Insulin signaling pathway | 2.209 | 8.88 × 10−4 |
| cfa04152:AMPK signaling pathway | 2.230 | 0.003 |
| cfa04510:Focal adhesion | 1.901 | 0.003 |
| cfa04722:Neurotrophin signaling pathway | 2.164 | 0.010 |
| cfa04012:ErbB signaling pathway | 2.384 | 0.013 |
| cfa04512:ECM-receptor interaction | 2.384 | 0.013 |
| Up-regulated miRNAs target genes pathway | ||
| Terms | FE 1 | FDR 2 |
| cfa04144:Endocytosis | 2.424 | 1.31 × 10−11 |
| cfa04810:Regulation of actin cytoskeleton | 2.273 | 2.78 × 10−7 |
| cfa05200:Pathways in cancer | 1.604 | 0.010 |
| cfa04710:Circadian rhythm | 3.536 | 0.060 |
| cfa05410:Hypertrophic cardiomyopathy (HCM) | 2.398 | 0.063 |
| cfa05414:Dilated cardiomyopathy | 2.346 | 0.065 |
| cfa04713:Circadian entrainment | 2.210 | 0.098 |
1 Fold enrichment. 2 False discovery rate.