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Metabolic derangements in the failing myocardium. AICAR: 5′-aminoimidazole-4-carboxyamide-ribonucleoside; MCD: malonyl-CoA decarboxylase; PGC-1α: proliferator-activated receptor-γ coactivator 1α; CPTI: carnitine palmitoyl transferase I; FFA: free fatty acids; GLUT: glucose transporters; PDH: pyruvate dehydrogenase; PCr: phosphocreatine, ANT: Anthracyclines, such as Doxorubicin; UCP: mitochondrial uncoupling proteins.
