Prespecified multivariate subgroup analysis of overall survival in the TAGS (TAS-102 Gastric Study) trial based on previous gastrectomy. This figure is adapted with permission of Elsevier Science and Technology Journals, from Shitara K et al. Trifluridine/tipiracil vs placebo in patients with heavily pretreated metastatic gastric cancer (TAGS): a randomized, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol 2018;19:1437-1448; permission conveyed through Copyright Clearance Center, Inc.