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. 2019 Oct 18;2:385. doi: 10.1038/s42003-019-0631-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Reaction scheme of CO formation by HypX. The reaction steps 1–3 take place in the N-terminal domain to form formyl-CoA. The conformational change of formyl-CoA proceeds in the reaction step 4 from the extended to the folded conformations, by which the formyl group will be placed at the active site in the C-terminal domain to form CO. Decarbonylation of formyl-CoA takes place to form CO in the reaction step 5