Figure 1.

MiR-126 regulated MAP kinase and DNA damage-related genes. Cancer pathway analysis was performed which includes 84 genes, representing nine major cancer pathways. Three independent experiments of paired OE33 cells either stably overexpressing miR-126 and an empty vector controls (CTR). (a) Shown is fold change in normalized gene expression and the P-value of statistical analyses (paired T-test). (b) MAP kinase MEK1 and DNA polymerase beta (POLB) were downregulated and telomeric repeat binding factor 1 (TERF1) significantly upregulated in samples overexpressing miR-126 compared to its empty vector control.