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. 2019 Aug 7;244(14):1210–1219. doi: 10.1177/1535370219868671

Figure 2.

Figure 2.

MiR-126 regulates cell death of OAC cells. (a) Flowcytometric analysis of cell death in untreated OE33 cells, transfected OE33 cells overexpressing miR-126, OE33 cells treated with the transfection reagent Lipofectamin alone and transfected OE33 cells overexpressing an empty vector. Shown are representative plots with on the y-axis 7-AAD and on the x-axis the FSC (forward side scatter). The gated 7-AAD positive cells represent the fraction of dead cells. Results of seven independent experiments show significantly less dead cells when overexpressing miR-126 compared to its empty vector. (b) Shown are representative plots of untreated OE33 cells, OE33 cells transfected with antagonized miR-126 (antimiR-126), OE33 cells treated with the transfection reagent Darmafect alone, and OE33 cells transfected with irrelevant antimiR control. On the y-axis 7-AAD and on the x-axis, the FITC-channel is shown. Dead cells are represented in the double positive fraction (upper right corner). Results from seven independent experiments show significantly more dead cells when antagonizing miR-126 compared to the control antimiR treated cells.