Table 2.
Univariable (UV) and multivariable (MV) analysis of prognostic (pre- and on-treatment) characteristics associated with poor five-year survival of 58 patients after combined neoadjuvant chemoradiotherapy and surgery.
| Parameters | HR (95% CI), P value, UV | HR (95% CI), P value, MV |
|---|---|---|
| Gender | ||
| Male | 1 (Ref) | x |
| Female | 0.664 (0.201–2.191), p = 0.502 | x |
| Age | ||
| <65 year | 1 (Ref) | x |
| ≥65 year | 1.698 (0.817–3.531), p = 0.156 | x |
| Location | ||
| Mid | 1 (Ref) | x |
| Distal | 0.406 (0.116–1.471), p = 0.157 | x |
| Junction | 0.809 (0.230–2.845), p = 0.741 | x |
| ypT-stagea | ||
| ypT0 | 1 (Ref) | 1 (Ref) |
| ypT1 | 1.607 (0.470–5.495), p = 0.449 | 0.880 (0.950–8.154), p = 0.910 |
| ypT2 | 1.010 (0.210–4.871), p = 0.990 | 0.617 (0.056–6.808), p = 0.693 |
| ypT3 | 3.965 (1.611–9.755), p = 0.003 | 2.019 (0.435–9.365), p = 0.369 |
| ypN-stagea | ||
| ypN0 | 1 (Ref) | 1 (Ref) |
| ypN1 | 1.245 (0.494–3.139), p = 0.642 | 1.299 (0.385–4.389), p = 0.673 |
| ypN2 | 6.336 (2.015–19.923), p = 0.002 | 4.606 (1.013–20.936), p = 0.048 |
| ypN3 | 4.917 (1.085–22.273), p = 0.039 | 1.995 (0.334–11.898), p = 0.449 |
| Radicality | ||
| R0 | 1 (Ref) | x |
| R1 | 2.506 (0.870–7.218), p = 0.089 | x |
| Tumor regression grade | ||
| TRG 1 | 1 (Ref) | x |
| TRG 2 | 2.453 (0.859–7.008), p = 0.094 | x |
| TRG 3 | 2.234 (0.829–6.020), p = 0.112 | x |
| TRG 4 | 2.637 (0.921–7.551), p = 0.071 | X |
| MiR-126 expressiona | ||
| Low | 1 (Ref) | 1 (ref) |
| High | 2.259 (1.053–4.846), p = 0.036 | 2.558 (1.052–6.220), p = 0.038 |
yp: after neoadjuvant treatment; after resection; p: pathology; R0, R1: radicality of the resection; TRG: tumor regression grade.
a
Taken into account for multivariable analysis.