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. 2019 Oct 18;10:4749. doi: 10.1038/s41467-019-12720-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Dynamic changes of enhancers’ landscape and occupancy of TSC-specific TFs during differentiation of TSCs. a Signal track images depicting occupancy of p300 around TGC (left panel) and SpT (right panel) markers in TSCs (red) and dTSCs (blue). b p300 occupancy networks of TGC (left panel) and SpT (right panel) marker genes in TSCs and dTSCs. Thickness of an arrow indicates occupancy score of p300. Relative gene expression (dTSCs/TSCs) is shown with color-coded heatmap. c A correlation heatmap of various TFs’ occupancy. Different functional classes of genes are color coded (Ctcf: blue; pluripotency factors: orange; PRC complex: green; TFs in TSCs: black; TFs in dTSCs: sky blue). Gradient color scale bar on the left indicates correlation coefficients. d Heatmaps depicting relative occupancy of TFs (dTSCs/TSCs) in TGC-related (left panel) and SpT-related (right panel) genes. Relative gene expression level (dTSCs/TSCs) is shown right beside the heatmaps