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. 2019 Oct 18;10:4768. doi: 10.1038/s41467-019-12824-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Early Igk rearrangement enables B cells to bypass the pre-BCR checkpoint. a Igk recombination can occur independent of Igh recombination as shown by semiquantitative PCR performed on ex vivo-derived fetal liver pro-B cells E17.5 (Lin⁻CD19⁺B220⁺IgM⁻CD2⁻CD117⁺) from wild-type and JHT mice. Each lane represents threefold serial dilutions of input DNA. DNA levels were normalized to iEκ b Representative flow-cytometry plots of fetal liver E17.5 cells from Igll1^−/−, B1.8, and Igll1^−/−;B1.8 littermates (from top to the bottom). Pro-B and pre-B cell gates are displayed as a percentage of CD19⁺IgM⁻ cells (left), IgM⁺ are displayed as a percentage of CD19⁺ cells (middle), and IgK⁺ histograms are displayed as a percentage of CD19⁺IgM⁺ cells (right)