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Hypoxia enhances Akt inhibitors to reduce pAkt levels, whereas the ability of VEGF inhibition to reduce pAkt is attenuated under hypoxia. Decision tree diagrams illustrating the key biomolecules dictating how pERK responses to inhibition of Akt phosphorylation (a) or VEGF binding (b). [D]/ki = 200 and 1000 for inhibition of Akt phosphorylation or VEGF binding, respectively
