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. 2019 Oct 18;9:14989. doi: 10.1038/s41598-019-51577-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Over-expression of EPO induced high hematocrit, low iron, low liver hepcidin expression, and splenomegaly in Tg6 mice. Biological markers of EPO activity were assessed in 6–8 weeks old female Tg6 mice and their littermates: (A) hematocrit, (B) total plasma iron, (C) liver hepcidin mRNA expression, and (D) spleen weight normalized to body weight. Data are means ± s.e.m.; n = 5–7 mice for each genotype. Significance was determined by unpaired t test and indicated as *p < 0.05, **p < 0.01.