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. 2019 Oct 18;9:14989. doi: 10.1038/s41598-019-51577-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Higher urinary excretion of Ca²⁺ and elevated levels of both forms of FGF23 in Tg6 mice. (A,B) Plasma and urine concentrations of phosphate (Pi) and total calcium (Ca²⁺) in 6–8 weeks old female Tg6 mice and their littermates. (C) Plasma intact FGF23, (D) plasma C-terminal fragment of FGF23, (E), plasma 1,25 (OH)₂ vitamin D_3, and (F) plasma parathyroid hormone (PTH). (G) Renal α-klotho protein expression was detected by immunoblotting in kidney extracts of Tg6 mice and their controls. Membranes were reblotted for β-actin. The β-actin to α-klotho ratio is shown as a graph. Data are means ± s.e.m.; n = 5–10 for each group of mice. Significance was determined by unpaired t test and indicated as *p < 0.05, **p < 0.01.