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. 2019 Oct 18;9:14954. doi: 10.1038/s41598-019-51004-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Higher level expression of plectin is associated with poor patient survival in lung adenocarcinoma patients and non-smokers, while opposite observation is on lung squamous carcinoma, and plectin isoforms 1a and 1f are highly expressed in NSCLC patients. (A–C) Kaplan–Meier survival plot of NSCLC patients³². (A) Lung adenocarcinoma, (B) non-smokers in NSCLC (adenocarcinoma and squamous cell carcinoma), (C) squamous cell carcinoma. Red and black bar indicate the high and low expression of plectin respectively. HR: hazard ratio. (D) RNAseq expression of plectin isoforms (1, 1a-1g) in NSCLC (n = 151) and SCLC+ Large Cell Neuroendocrine (NE, n = 84) cell lines. Plectin mutations were found in 14 NSCLC and 4 SCLC/NE cell lines (short bars at right).