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. 2019 Sep 24;20(19):4742. doi: 10.3390/ijms20194742

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Relative mRNA levels of HK2, PFKFB4, ALDOC, ENO2, PDK1, and LDHA normalized each to the RPL9 mRNA level, after the application of 5 mM L-glutamine (Q) corresponding to Figure 1 (lanes 5–8), 1% fetal bovine serum (S) (lanes 3, 4, 7, and 8) and/or 5 nM HIF1α-specific siRNA (si) (lanes 2, 4, 6, and 8) or medium without glutamine, serum and siRNA (c -control) lane 1 under normoxic conditions in the MDA-MB-231 cells 24 h after the start of the treatment. The transcription of these genes was significantly regulated by HIF1 under normoxic conditions due to the stabilization of HIF1α via glutamine and fetal bovine serum. (For p-values, please refer to Supplemental Tables S1 and S2; see also Supplemental Figure S16).

Relative mRNA levels of HK2, PFKFB4, ALDOC, ENO2, PDK1, and LDHA normalized each to the RPL9 mRNA level, after the application of 5 mM L-glutamine (Q) corresponding to Figure 1 (lanes 5–8), 1% fetal bovine serum (S) (lanes 3, 4, 7, and 8) and/or 5 nM HIF1α-specific siRNA (si) (lanes 2, 4, 6, and 8) or medium without glutamine, serum and siRNA (c -control) lane 1 under normoxic conditions in the MDA-MB-231 cells 24 h after the start of the treatment. The transcription of these genes was significantly regulated by HIF1 under normoxic conditions due to the stabilization of HIF1α via glutamine and fetal bovine serum. (For p-values, please refer to Supplemental Tables S1 and S2; see also Supplemental Figure S16).